Radiosensitivity is defined as a measure of the degree of response of a cell or an organism to ionizing radiation (IR). Patients treated by the same dose experience different levels of damage. In addition, radiation-sensitive individuals have more severe adverse reactions to radiotherapy. The reason is mainly related to differences in susceptibility to radiation damage. A single nucleotide polymorphism (SNP) is a DNA sequence polymorphisms caused by a single nucleotide variationinthegenome.

CIRP research team investigated the association between individual radiosensitivity and SNPs using blood samples collected from 68 non-smoking healthy male volunteers. Irradiation of blood samples, chromosome aberration analysis and classification, DNA extraction and genotyping, and statistical analyses were conducted to study the correlation between allele frequency and association between genotypes and radiosensitivity. The research classified the radiosensitive population by chromosome aberration rate, then discussed the association between SNPs and radiosensitivity by logistic regression under different genetic models. The results suggest that three SNPs, respectively rs13018957 (TRIP12), rs1700490 (UIMC1) and rs2022302 (POLN) may be biomarkers indicating radiosensitivity. It provides research basis for individual radiosensitivity assessment and radiotherapy adverse reaction prediction, which will enhance our opportunity to benefit from medical applications exploiting radiation and protect individuals from radiation encountered during daily life.

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